池毓烺,副教授,中国科学院大学博士,“清源学者奖励计划”特聘教授,硕士生导师,九三学社社员,福建省高层次人才,泉州人才“港湾计划”引进高层次人才(第三层次)。主要从事污染物的健康效应及分子毒理学机制、典型区域的环境微生态与健康关系的研究。先后主持和参加各级科研项目10多项,包括主持国家自然科学基金项目1项(国家级)、主持福建省自然科学基金面上项目2项(省级)、主持中国科学院重点实验室项目2项、主持交通运输部水运科学研究所委托项目1项(横向)。参与获评2021年度福建省科技进步三等奖。目前已在国内外环境领域主流期刊上发表SCI论文36篇(包括Science of the Total Environment、Environmental Pollution、Chemosphere等Top期刊)。担任iMeta期刊青年编委。
代表性论文:
1. Ding, S., Chang, J., Zhang, W., Ji, S., Chi Y*. (2024). Environmental microbial diversity and water pollution characteristics resulted from 150 km coastline in Quanzhou Bay offshore area. Frontiers in Microbiology. 15:1438133.
2. Chi, Y., Zhu, L., Wang, Y., Peng, C., Lin, Y., Ji, S., & Wei, J. (2024). Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice. Toxicology, 153798.
3. Min, L., Chi, Y*., Dong, S*. (2020). Gut microbiota health closely associates with PCB153-derived risk of host diseases. Ecotoxicology and Environmental Safety. 203, 15,111041.
4. Wang, H., Zhao, P., Huang, Q., Chi, Y*., Dong, S*., Fan, J. (2019). Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons. Chemosphere, 229, 618-630.
5. Chi, Y., Lin, Y., Lu, Y., Huang, Q., Ye, G., & Dong, S*. (2019). Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease. Science of the Total Environment, 653, 274-282.
6. Chi, Y., Lin, Y., Zhu, H., Huang, Q., Ye, G., & Dong, S*. (2018). PCBs-high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice. Environmental Pollution, 239, 332-341.
7. Chi, Y., Wang, H., Lin, Y., Lu, Y., Huang, Q., Ye, G., & Dong, S*. (2019). Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice. Toxicology, 420, 11-20.
8. Chi, Y., Zhang, H., Huang, Q., Lin, Y., Ye, G., Zhu, H., & Dong, S*. (2018). Environmental risk assessment of selected organic chemicals based on TOC test and QSAR estimation models. Journal of Environmental Sciences, 64, 23-31.
9. Chi, Y., Huang, Q., Lin, Y., Ye, G., Zhu, H., & Dong, S*. (2018). Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells. Journal of Environmental Sciences, 66, 155-164.
10. Chi, Y., Huang, Q., Zhang, H., Chen, Y., & Dong, S*. (2016). In situ combined chemical and biological assessment of estrogenic pollution in a water recycling system. Journal of Environmental Sciences, 43, 216-223.
11. Chi, Y. L., Zhang, H. Y., Xue, J. H., Hao, J., Liu, M. F., & Wei, X. Y*. (2009). N 2-(1-Methoxycarbonylethyl) guanosine, a new nucleoside coupled with an amino acid derivative from Amanita exitialis. Chinese Chemical Letters, 20 (7), 830-832.
12. Ye, G., Ding, D., Gao, H., Chi, Y., Chen, J., Wu, Z., ... & Dong, S*. (2019). Comprehensive metabolic responses of HepG2 cells to fine particulate matter exposure: Insights from an untargeted metabolomics. Science of The Total Environment, 691, 874-884.
13. Ding, D., Ye, G., Lin, Y., Lu, Y., Zhang, H., Zhang, X., Hong, Z., Huang, Q., Chi, Y.,... & Dong, S*. (2019). MicroRNA-26a-CD36 signaling pathway: Pivotal role in lipid accumulation in hepatocytes induced by PM2. 5 liposoluble extracts. Environmental Pollution, 248, 269-278.
14. Ye, G., Gao, H., Wang, Z., Lin, Y., Liao, X., Zhang, H., Chi, Y., Zhu, H., Dong, S*. (2019). PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression. Cell Death & Disease, 10(2), 39-39.
15. Huang, Q., Liu, Y., Chen, Y., Fang, C., Chi, Y., Zhu, H., ... & Dong, S*. (2018). New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure. Environmental Pollution, 242, 914-921.
16. Huang, Q., Chen, Y., Lin, L., Liu, Y., Chi, Y., Lin, Y., ... & Dong, S*. (2017). Different effects of bisphenol A and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses. Science of the Total Environment, 595, 752-758.
17. Lu, Y. Y., Lin, Y., Ding, D. X., Su, S., Chi, Q. Q., Zhang, Y. C., ... & Chi, Y. L. (2017). MiR-26a functions as a tumor suppressor in ambient particulate matter-bound metal-triggered lung cancer cell metastasis by targeting LIN28B–IL6–STAT3 axis. Archives of toxicology, 92:1023-1035.
18. Lin, Y., Ding, D., Huang, Q., Liu, Q., Lu, H., Liu, Y., Chi, Y., ... & Wei, J*. (2017). Downregulation of miR-192 Causes Hepatic Steatosis and Lipid Accumulation by Inducing SREBF1: Novel Mechanism for Bisphenol A-triggered Non-alcoholic Fatty Liver Disease. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1862(9), 869-882.
详细论文链接:
https://orcid.org/0000-0002-0443-5189
https://www.researchgate.net/profile/Yulang-Chi
科研项目:
1. 国家自然科学基金项目,41701576,基于原位鱼体暴露研究近岸海域中典型环境雌激素的生态毒理效应,2018/01-2020/12,28.8万元,已结题,主持。
2. “清源学者奖励计划”特聘教授项目,泉师人【2022】9号,2022/01-2024/12,80万元,主持。
3. 泉州人才“港湾计划”引进高层次人才项目(第三层次),F202130065Y,2021/11-2027/11,50万元,主持。
4. 中国科学院城市环境与健康重点实验室跨组合作项目,KLUEH-C-201901,东南沿海典型城市(区域)PM2.5的内分泌干扰及代谢途径的健康效应研究,2019/03-2021/02,40万元,已结题,主持。
5. 中国科学院城市环境与健康重点实验室跨组合作项目,KLUEH-C-201802,砷糖及砷糖磷脂的生物合成机制、代谢途径和健康效应研究,2018/03-2020/02,40万元,已结题,主持。
6. 福建省自然科学基金面上项目,2018J01022,应用原位鱼体暴露研究近岸海域典型环境雌激素的生态毒理效应,2018/04-2021/04,4万元,已结题,主持。
7. 威尼斯9499登录入口引进人才科研启动费,H19041,PCB77暴露对小鼠肠道微生物及宿主健康的影响,2020/01-2022/12,20万元,已结题,主持。
8. 福建省中青年教师教育科研项目,JAT190525,典型多氯联苯诱导肠道微生物紊乱和宿主肝脏相关疾病的研究,2020/01-2021/12,2万元,已结题,主持。
9. 交通运输部水运科学研究所委托项目,2021KH16,进境船舶压载舱沉积物携带外来浮游植物对生态环境安全的影响实验研究,2020/06 -2021/06, 7.8万元,已结题,主持。
10. 国家自然科学基金面上项目,21777158,双酚A暴露经由雌激素受体影响谷氨酸能神经网络发育及功能的分子机制,2018/01-2021/12,64万元,已结题,参加。
11. 国家自然科学基金面上项目,21477124,从胰岛素信号转导通路探讨BPA促进动脉粥样硬化的作用机制,2015/01-2018/12,86万元,已结题,参加。
12. 国家自然科学基金青年项目,21507128,多平台代谢组学技术研究苯并芘暴露下肺的代谢紊乱作用机制,2016/01-2018/12,22万元,已结题,参加。
13. 福建省中科院STS计划项目,2016T3005,肠道微生态精准调控技术研发,2016/08-2019/07,35万元,已结题,参加。
14. 福建省自然科学基金项目, 2017J01028,双酚A通过microRNA诱发非酒精性脂肪肝疾病发生发展的分子机制探讨,4万元,2017/04-2020/03,已结题,参加。
15. 福建省科技计划引导性项目, 2018Y0081,沿海区域环境指示生物的污染物负荷数据库构建及应用,2018/04-2020/04,15万元,已结题,参加。
16. 福建省自然科学基金项目,2018J01020,苯并芘暴露经由芳香烃受体诱发巨噬细胞脂质累积的分子机制,2018/04-2021/04,4万元,已结题,参加。